My main research interest in the genetic field is to map genetic variation for common complex diseases. The current focus of my group is on hypertension / metabolic syndrome – related disorders. We used both linkage and association approaches in a genome-wide scope to search for new genetic variants for these complex diseases. Concepts and related information and techniques on endophenotype, linkage disequilibrium, and tag-SNP are taken into consideration in the process of finding genes. Methodology studies on DNA pooling and dissecting ethnicity are underway. Infrastructures for multi-center study, biospecimen sharing, quality control, and ELSI related issues have been gradually established.
Professor, Division of Epidemiology and Genetics, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
A PhD in Nutrition Epidemiology from Cornell University, USA, was followed by post-doctoral research in Cardiovascular Epidemiology at Dept. of Community Health and Preventive Medicine, Northwestern University, and an academic position in the Institute of Biomedical Sciences, Academia Sinica (AS), where she initiated a longitudinal community cohort study on cardiovascular disease development and led the Nutrition and Health Survey in Taiwan in the past 15 years. She became a full professor of AS in 1994 and modified her research path toward gene mapping for complex diseases with a major focus on hypertension and related diseases. She is now the leader of an AS genetic program project to map novel genes for five important common complex diseases in Taiwan Han Chinese.