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Optical Biomedical Imaging and Sensing



Andrei Zvyagin, PhD

Associate Professor

BMP group head

Andrei's research interests lie exclusively in the area of Biophotonics, focused on optical biomedical imaging and sensing, directed towards imaging in live tissue and cells, and aspired by the possibility of detecting single biomolecules. His research horizons are, otherwise, broad and include optical scanning near-field microscopy, optical coherence tomography, fibre optic spectroscopy for biological assaying in vivo , multiphoton microscopy, photoreceptor optics, and novel optical labels for intracellular imaging.

Andrei was born in Russia. He received a Diploma from the Moscow Engineering Physics Institute, Russia, and the PhD degree in Engineering from the Tokyo Institute of Technology, in 1984 and 1997, respectively.

From 1984 to 1994, he spanned a range of positions from an Engineer to Senior Research Scientist in the Institute of Metrology for Time and Space, Moscow, Russia, focussing on research and metrological aspects of time and frequency standards based on trapped ions. From 1998 to 2000, he was a Postdoctoral Fellow in the Optical+Biomedical Engineering Laboratory, The University of Western Australia, and from 2000-2004, became an Australian Postdoctoral Fellow, studying optical coherence tomography for biomedical imaging applications. From 2004-2005, he joined the Centre for Biophotonics and Laser Science as a Lecturer/Australian Research Fellow, and was promoted to a Senior Lecturer/ Australian Research Fellow since 2006. From 2007, he is an Associate Professor in Physics, Macquarie University, Sydney.

Publication List

Phone: +61 2 9850 7760
Fax: +61 2 9850 8115
Room: 2.707, E6B 

Dr Liuen Liang (Olivia), Research Associate


Olivia received her BSc degree in 2010 in Polymer Science and Engineering from South China University of Technology. Afterwards, she moved to Australia and continued her postgraduate study in the department of Materials Science and Engineering in the University of New South Wales. During her master study, she worked on the synthesis and mechanism investigation of metal nanomaterials (silver and gold nanoparticles). After receiving her MSc degree in Nanotechnology in 2012, she was awarded an MQRES scholarship by Macquarie University and conduct her PhD study in the department of Biomedical Sciences. Her PhD study focused on the development of upconversion nanoparticles for cancer diagnosis and treatment. In Jan of 2017, she completed her PhD and joined the Physics and Astronomy Department of Macquarie University. She is now carrying out her postdoctoral work as a Research Associate with A/Prof. Andrei Zvyagin. Her current project aims to develop a novel biofunctional nanohybrid for background-free imaging of single molecule in cells and tissues.

Olivia's major interest include development of photoluminescent nanoparticles for optical imaging, design of biohybrid nanostructures for theranostic applications, and investigation of nano-/bio-interface chemistry.

Tel: +61 2 9850 9547 


Dr Xiaohong Yang (Carrie), Visiting Fellow

Carrie obtained her BEng and MSc degrees in Dalian Nationality University in China and Myongji University in South Korea. In the year 2014, she obtained PhD degree from the school of Material Science and Engineering in the University of New South Wales. Afterwards, Carrie worked as a lecturer in the School of Metallurgy, Northeastern University in China. Her research focues on the development of innovative strategies to synthesize noble metal or semiconductor nanoparticles and their nanocomposites, to engineer functional assemblies, and to understand the underlying fundamentals for functionality control in energy, environmental and biomedical applications, particularly in gas sensing system photocatalysis. 

Currently, she is a visiting honorary research fellow with A/Prof. Andrei Zvyagin. Her project is large-scale production of biocompatible nanophosphor as phosphorescent probes for biological labelling of cells.


1. Honorary research fellow, Department of Physics and Astronomy, Macquarie University, Sydney, Australia.

2. Senior Researcher, Laboratory of Experimental Morphology of the Institute of Molecular Medicine, Sechenov First Moscow Medical University, Russia

3. Lecturer, School of Metallurgy, Northeastern University, China.


 More details may be found at:

Dr Wei Deng, Honorary Senior Researcher

Dr Wei Deng was awarded her PhD in Chemistry at Macquarie University in 2011 and received an ARC DECRA Fellowship in 2012. Deng worked at Macquarie University from Apr, 2013 to June, 2018 as a Research Fellow. Since June 2018, she has been conducting her research at UNSW. Deng’s research interest is mainly focused on development of nanocarriers incorporating drug/gene for cancer diagnostics. In particular, She has led the projects on development of diverse triggerable nanomaterials for cancer treatments, including an X-ray (or light) triggered liposomal delivery platform and light-triggered polymer nanocarriers for enhanced photodynamic therapy. These engineered gene/drug delivery systems are now a major strength of her research profile, attracting internal, cross-disciplinary and industry collaborations.



Dr Sandhya Clement, Honorary Researcher

Dr. Sandhya Clement received her  PhD degree from Physics & Astronomy Department, Macquarie University, Australia in the year 2016 for the thesis titled "Towards photodynamic therapy with ionising radiation: nanoparticle-mediated singlet oxygen generation and quantification". She is now working as a research associate with Prof. Ewa Goldys in the Graduate School of Biomedical Engineering, University of New South Wales. Her research is mainly focused on application of nanoscintillators, metal nanoparticles and polymer nanoparticles in light and X-ray mediated photodynamic therapy.

Tel:+61 405 155 133 

E-mail:  or


Vlada Rozova, PhD candidate

Vlada graduated from the Department of Computational Mathematics and Cybernetics of Lomonosov Moscow State University, Russia. During her master study, she developed a mathematical model of interactions between tumours and the immune system in the presence of chemotherapy. After receiving her MSc degree in 2015, Vlada spent a year working in a company providing model-based drug development solutions for global pharmaceutical companies and acquired experience in quantitative systems pharmacology, pharmacokinetic-pharmacodynamic and population modelling.

In 2016, Vlada was awarded an iMQRES scholarship to pursue a Ph.D. in physics in Macquarie University. Under the supervision of A/Prof. Andrei Zvyagin, she is conducting her research on mathematical modelling of tumour growth in tissue engineering constructs. The goal of her PhD project is to develop a reliable mathematical model of early metastasis validated by the experiments carried out in the group.

Vlada’s research interests lie in the field of Biomathematics, focused on mathematical modelling of biomedical problems, especially related to cancer.

Tel:+61 402 688 325



  • V. Rozova, A. Bratus. “Therapy strategy in tumour cells and immune system interaction mathematical model”. Applicable Analysis (2016).

  • V. Rozova, E. Khaydukov, A. Zvyagin. “Incoherent wavefront reconstruction by a retroemission device containing a thin fluorescent film: Theory”. Applied Optics, Vol.55 (21), pp. 5554-5563 (2016).


Dmitry Polikarpov, PhD candidate

Dmitry Polikarpov obtained his M.D. from Russian National Research Medical University, Moscow, Russia. From 2011 to 2015, he was researching the possibility of using magnetic nanoparticles for targeted drug delivery. He applied Mössbauer spectroscopy in the series of in vivo experiments related to the clearance of magnetic nanoparticles from the brain of a rat and studied its distribution within the body of a rat. In 2015, he was awarded an International Research Training Pathway Scholarship and now, being a postgraduate student in Macquarie University, he investigates the possibilities of application of photoluminescent nanomaterials for diagnosis and therapy of bladder cancer. His major interests include targeted therapy, cancer treatment and diagnostics, photoluminescent nanomaterials, magnetic nanoparticles and Mössbauer spectroscopy.

Dmitry's Principle Supervisor is Prof David Gillatt, Director of Medical Services, Faculty of Medicine and Health Sciences, Macquarie University; A/Prof Andrei Zvyagin is Co-Supervisor.

Tel: +61 413 474 975



Alexey Rzhe, PhD candidate


In 2015, Alexey graduated as a medical doctor (MD) from Sechenov University in Moscow. After, he continued as a researcher and completed MSc at Griffith Univesity, investigating microneedles as the technique of drug delivery enhancement in diverse organs and tissues. In March 2018, Alexey started as a PhD candidate at Macquarie University in the Centre for Nanoscale and Biophotonics. His current research interests are mainly related to the investigation of targeted drug delivery techniques, particularly - microneedles, cancer treatment and diagnostics, and broad scope of investigations in the field of urology.

Tel: +61 457 248 832